activin type ii b receptor Search Results


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Expression of myostatin and phosphorylation of Smad1/5/8 in gastrocnemius and diaphragm muscles. Transcrip level of myostatin ( A ) and <t>activin</t> <t>type</t> <t>IIb</t> <t>receptor</t> ( B ). Immunoblot analysis of Smad2/3 phosphorylation on Ser423 and Ser425 (upper panel) and quantification of Smad2/3 phosphorylation level (lower panel) ( C ). Immunoblot analysis of Smad1/5/8 phosphorylation on Ser463, Ser465, Ser 426 and Ser428 (upper panel) and quantification of Smad1/5/8 phosphorylation level (lower panel) ( D ). D1: one day after CLP; D4: 4 days after CLP; D7: 7 days after CLP. All data are expressed relative to sham values and presented as means ± SEM (n = 7–8/group). a: significantly different from Sham; b: significantly different from D1; c: significantly different from D4; †: significantly different from gastrocnemius muscle at the same time point.
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Expression of myostatin and phosphorylation of Smad1/5/8 in gastrocnemius and diaphragm muscles. Transcrip level of myostatin ( A ) and <t>activin</t> <t>type</t> <t>IIb</t> <t>receptor</t> ( B ). Immunoblot analysis of Smad2/3 phosphorylation on Ser423 and Ser425 (upper panel) and quantification of Smad2/3 phosphorylation level (lower panel) ( C ). Immunoblot analysis of Smad1/5/8 phosphorylation on Ser463, Ser465, Ser 426 and Ser428 (upper panel) and quantification of Smad1/5/8 phosphorylation level (lower panel) ( D ). D1: one day after CLP; D4: 4 days after CLP; D7: 7 days after CLP. All data are expressed relative to sham values and presented as means ± SEM (n = 7–8/group). a: significantly different from Sham; b: significantly different from D1; c: significantly different from D4; †: significantly different from gastrocnemius muscle at the same time point.
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Expression of myostatin and phosphorylation of Smad1/5/8 in gastrocnemius and diaphragm muscles. Transcrip level of myostatin ( A ) and <t>activin</t> <t>type</t> <t>IIb</t> <t>receptor</t> ( B ). Immunoblot analysis of Smad2/3 phosphorylation on Ser423 and Ser425 (upper panel) and quantification of Smad2/3 phosphorylation level (lower panel) ( C ). Immunoblot analysis of Smad1/5/8 phosphorylation on Ser463, Ser465, Ser 426 and Ser428 (upper panel) and quantification of Smad1/5/8 phosphorylation level (lower panel) ( D ). D1: one day after CLP; D4: 4 days after CLP; D7: 7 days after CLP. All data are expressed relative to sham values and presented as means ± SEM (n = 7–8/group). a: significantly different from Sham; b: significantly different from D1; c: significantly different from D4; †: significantly different from gastrocnemius muscle at the same time point.
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Expression of myostatin and phosphorylation of Smad1/5/8 in gastrocnemius and diaphragm muscles. Transcrip level of myostatin ( A ) and <t>activin</t> <t>type</t> <t>IIb</t> <t>receptor</t> ( B ). Immunoblot analysis of Smad2/3 phosphorylation on Ser423 and Ser425 (upper panel) and quantification of Smad2/3 phosphorylation level (lower panel) ( C ). Immunoblot analysis of Smad1/5/8 phosphorylation on Ser463, Ser465, Ser 426 and Ser428 (upper panel) and quantification of Smad1/5/8 phosphorylation level (lower panel) ( D ). D1: one day after CLP; D4: 4 days after CLP; D7: 7 days after CLP. All data are expressed relative to sham values and presented as means ± SEM (n = 7–8/group). a: significantly different from Sham; b: significantly different from D1; c: significantly different from D4; †: significantly different from gastrocnemius muscle at the same time point.
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Expression of myostatin and phosphorylation of Smad1/5/8 in gastrocnemius and diaphragm muscles. Transcrip level of myostatin ( A ) and activin type IIb receptor ( B ). Immunoblot analysis of Smad2/3 phosphorylation on Ser423 and Ser425 (upper panel) and quantification of Smad2/3 phosphorylation level (lower panel) ( C ). Immunoblot analysis of Smad1/5/8 phosphorylation on Ser463, Ser465, Ser 426 and Ser428 (upper panel) and quantification of Smad1/5/8 phosphorylation level (lower panel) ( D ). D1: one day after CLP; D4: 4 days after CLP; D7: 7 days after CLP. All data are expressed relative to sham values and presented as means ± SEM (n = 7–8/group). a: significantly different from Sham; b: significantly different from D1; c: significantly different from D4; †: significantly different from gastrocnemius muscle at the same time point.

Journal: Scientific Reports

Article Title: Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

doi: 10.1038/s41598-017-11440-5

Figure Lengend Snippet: Expression of myostatin and phosphorylation of Smad1/5/8 in gastrocnemius and diaphragm muscles. Transcrip level of myostatin ( A ) and activin type IIb receptor ( B ). Immunoblot analysis of Smad2/3 phosphorylation on Ser423 and Ser425 (upper panel) and quantification of Smad2/3 phosphorylation level (lower panel) ( C ). Immunoblot analysis of Smad1/5/8 phosphorylation on Ser463, Ser465, Ser 426 and Ser428 (upper panel) and quantification of Smad1/5/8 phosphorylation level (lower panel) ( D ). D1: one day after CLP; D4: 4 days after CLP; D7: 7 days after CLP. All data are expressed relative to sham values and presented as means ± SEM (n = 7–8/group). a: significantly different from Sham; b: significantly different from D1; c: significantly different from D4; †: significantly different from gastrocnemius muscle at the same time point.

Article Snippet: Transcrip level of myostatin ( A ) and activin type IIb receptor ( B ).

Techniques: Expressing, Phospho-proteomics, Muscles, Western Blot